Yale School of Medicine
Education
Heinrich-Heine-Universität Düsseldorf (Germany), 1991-1998, Medicine; Université de Nantes, INSERM (Nantes, France), 1995, Immunology; Unité de Biologie Moléculaire, Institut Pasteur, (France), 1997, Molecular Biology; Heinrich-Heine-Universität Düsseldorf, 2000, MD;
Institute of Genetics, Universität zu Köln (Germany), 2003, MD/PhD, Immunology
Professional Area
Lymphocyte development, B- and T-cell antigen receptor signaling, leukemia, lymphoma, signal transduction, PI3K signaling, cell size regulation, mitochondrial biogenesis, energy metabolism, autoimmune diseases, cytokine receptor signaling, cell engineering, optogenetics
Citation
For fundamental contributions to understanding mechanisms of malignant transformation and clonal evolution towards B-cell leukemia and lymphoma, uncovering negative B-cell selection mechanisms in the immune system that are designed to clear autoreactive B-cells and how these mechanisms can be harnessed to overcome drug-resistance in refractory autoimmune diseases and B-cell malignancies.